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EVI1 / AML1 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q03112 |
| Other Accession | NP_001098547.3, NP_005232.2, NP_004982.2, NP_001157471.1, NP_001157472.1, 2122, 14013 (mouse) |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 138136 Da |
| Gene ID | 2122 |
|---|---|
| Other Names | MDS1 and EVI1 complex locus protein EVI1, Ecotropic virus integration site 1 protein homolog, EVI-1, MECOM, EVI1 |
| Dilution | WB~~1:1000 E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | EVI1 / AML1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MECOM (HGNC:3498) |
|---|---|
| Function | [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. |
| Cellular Location | Nucleus. Nucleus speckle. Cytoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize all reported isoforms (NP_001098547.3; NP_005232.2; NP_004982.2; NP_001157471.1; NP_001157472.1). Reported variants represent identical protein: NP_001098548.2, NP_005232.2
References
Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes. Konrad TA, Karger A, Hackl H, Schwarzinger I, Herbacek I, Wieser R, Journal of leukocyte biology 2009 Oct 86 (4): 813-22. PMID: 19605700
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