CPLA2-zeta Antibody (internal region, near C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | Q68DD2 |
Other Accession | NP_998765.3, 255189 |
Predicted | Human, Mouse, Rat, Cow |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 95082 Da |
Gene ID | 255189 |
---|---|
Other Names | Cytosolic phospholipase A2 zeta, cPLA2-zeta, 3.1.1.4, Phospholipase A2 group IVF, PLA2G4F |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CPLA2-zeta Antibody (internal region, near C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PLA2G4F |
---|---|
Function | Has calcium-dependent phospholipase and lysophospholipase activities with a potential role in membrane lipid remodeling and biosynthesis of lipid mediators (PubMed:29158256). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:29158256). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis (PubMed:29158256). In myocardial mitochondria, plays a major role in arachidonate release that is metabolically channeled to the formation of cardioprotective eicosanoids, epoxyeicosatrienoates (EETs) (PubMed:29158256). |
Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q50L41}. Cell membrane {ECO:0000250|UniProtKB:Q50L41}; Peripheral membrane protein. Mitochondrion |
Tissue Location | Expressed in myocardium (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
References
Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}. Ohto T, Uozumi N, Hirabayashi T, Shimizu T, The Journal of biological chemistry 2005 Jul 280 (26): 24576-83. PMID: 15866882
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