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MLLT10 / AF10 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P55197 |
| Other Accession | NP_004632.1, NP_001009569.1, 8028, 17354 (mouse), 361285 (rat) |
| Reactivity | Rat |
| Predicted | Human, Mouse, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 113320 Da |
| Gene ID | 8028 |
|---|---|
| Other Names | Protein AF-10, ALL1-fused gene from chromosome 10 protein, MLLT10, AF10 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MLLT10 / AF10 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MLLT10 (HGNC:16063) |
|---|---|
| Function | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed abundantly in testis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (NP_004632.1; NP_001009569.1).
References
Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias. Lin YH, Kakadia PM, Chen Y, Li YQ, Deshpande AJ, Buske C, Zhang KL, Zhang Y, Xu GL, Bohlander SK, Blood 2009 Jul 114 (3): 651-8. PMID: 19443658
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