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GM2A (aa 179-189) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P17900 |
| Other Accession | NP_000396.2, 2760, 14667 (mouse), 282838 (rat) |
| Reactivity | Human, Rat |
| Predicted | Mouse, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 20838 Da |
| Gene ID | 2760 |
|---|---|
| Other Names | Ganglioside GM2 activator, Cerebroside sulfate activator protein, GM2-AP, Sphingolipid activator protein 3, SAP-3, Ganglioside GM2 activator isoform short, GM2A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GM2A (aa 179-189) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GM2A (HGNC:4367) |
|---|---|
| Function | The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium- independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D- galactosamine and conversion to GM3 (By similarity). Has cholesterol transfer activity (PubMed:17552909). |
| Cellular Location | Lysosome. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize isoform 1 (NP_000396.2) only.
References
Ganglioside GM2-tetraspanin CD82 complex inhibits met and its cross-talk with integrins, providing a basis for control of cell motility through glycosynapse. Todeschini AR, Dos Santos JN, Handa K, Hakomori SI, The Journal of biological chemistry 2007 Mar 282 (11): 8123-33. PMID: 17215249
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