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MPV17 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P39210 |
| Other Accession | NP_002428.1, 4358, 17527 (mouse), 360463 (rat) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 19733 Da |
| Gene ID | 4358 |
|---|---|
| Other Names | Protein Mpv17, MPV17 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MPV17 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MPV17 |
|---|---|
| Function | Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis (PubMed:25861990). Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance (PubMed:26760297). May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (By similarity). |
| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
| Tissue Location | Ubiquitous. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain and heart. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
MPV17-associated hepatocerebral mitochondrial DNA depletion syndrome: new patients and novel mutations. El-Hattab AW, Li FY, Schmitt E, Zhang S, Craigen WJ, Wong LJ, Molecular genetics and metabolism 2010 Mar 99 (3): 300-8. PMID: 20074988
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