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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > AGTPBP1 / NNA1 Antibody (internal region)
AGTPBP1 / NNA1 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UPW5 |
| Other Accession | NP_056054.2, 23287, 67269 (mouse), 290986 (rat) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 138448 Da |
| Gene ID | 23287 |
|---|---|
| Other Names | Cytosolic carboxypeptidase 1, 3.4.17.-, ATP/GTP-binding protein 1, Nervous system nuclear protein induced by axotomy protein 1 homolog, AGTPBP1, CCP1, KIAA1035, NNA1 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AGTPBP1 / NNA1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AGTPBP1 (HGNC:17258) |
|---|---|
| Function | Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed:22170066, PubMed:24022482, PubMed:30420557). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta- tubulin (PubMed:22170066, PubMed:24022482, PubMed:30420557). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:24022482). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK (PubMed:22170066). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216). |
| Cellular Location | Cytoplasm. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q641K1}. Nucleus Mitochondrion {ECO:0000250|UniProtKB:Q641K1}. Note=Localizes in both the cytoplasm and nuclei of interphase and dividing cells |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Knockout mouse models of sperm flagellum anomalies. Escalier D. Hum Reprod
Update. 2006 Jul-Aug;12(4):449-61. PMID: 16565154
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$ 341.00
Cat# AF3367a
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