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SLC47A2 Antibody (internal region, near C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q86VL8 |
| Other Accession | NP_690872.2, NP_001093116.1, 146802 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 65085 Da |
| Gene ID | 146802 |
|---|---|
| Other Names | Multidrug and toxin extrusion protein 2, MATE-2, hMATE-2, Kidney-specific H(+)/organic cation antiporter, Solute carrier family 47 member 2, SLC47A2, MATE2 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC47A2 Antibody (internal region, near C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC47A2 (HGNC:26439) |
|---|---|
| Synonyms | MATE2 |
| Function | Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively charged at physiological pH, cimetidine, the platinum-based drugs cisplatin and oxaliplatin or the antidiabetic drug metformin. Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Detected in the renal urinary tubules. |
| Tissue Location | [Isoform 1]: High expression in kidney. Very small expression in adrenal gland and lung. [Isoform 6]: Ubiquitously expressed in all tissues examined except the kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (NP_690872.2; NP_001093116.1).
References
Functional characteristics of two human MATE transporters: kinetics of cimetidine transport and profiles of inhibition by various compounds. Ohta KY, Inoue K, Yasujima T, Ishimaru M, Yuasa H, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2009 12 (3): 388-96. PMID: 20067714
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