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Calcipressin-1 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P53805 |
| Other Accession | NP_004405.3, NP_981962.1, NP_981963.1, 1827, 54720 (mouse), 266766 (rat) |
| Reactivity | Mouse |
| Predicted | Human, Rat, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 28079 Da |
| Gene ID | 1827 |
|---|---|
| Other Names | Calcipressin-1, Adapt78, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Regulator of calcineurin 1, RCAN1, ADAPT78, CSP1, DSC1, DSCR1 |
| Dilution | WB~~1:1000 E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Calcipressin-1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RCAN1 |
|---|---|
| Synonyms | ADAPT78, CSP1, DSC1, DSCR1 |
| Function | Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity). |
| Tissue Location | Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize all three reported isoforms (NP_004405.3; NP_981962.1; NP_981963.1).
References
Integrative genomics identifies DSCR1 (RCAN1) as a novel NFAT-dependent mediator of phenotypic modulation in vascular smooth muscle cells. Lee MY, Garvey SM, Baras AS, Lemmon JA, Gomez MF, Schoppee Bortz PD, Daum G, LeBoeuf RC, Wamhoff BR, Human molecular genetics 2010 Feb 19 (3): 468-79. PMID: 19926569
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