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HSPC117 (aa125-138) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, Pep-ELISA |
|---|---|
| Primary Accession | Q9Y3I0 |
| Other Accession | NP_055121.1, 51493, 28088 (mouse), 362855 (rat) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Pig, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 55210 Da |
| Gene ID | 51493 |
|---|---|
| Other Names | tRNA-splicing ligase RtcB homolog {ECO:0000255|HAMAP-Rule:MF_03144}, 6.5.1.3 {ECO:0000255|HAMAP-Rule:MF_03144}, RTCB {ECO:0000255|HAMAP-Rule:MF_03144}, C22orf28 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HSPC117 (aa125-138) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RTCB {ECO:0000255|HAMAP-Rule:MF_03144} |
|---|---|
| Synonyms | C22orf28 |
| Function | Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. |
| Cellular Location | Nucleus. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03144, ECO:0000269|PubMed:24608264} Note=Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
HSPC117 is the essential subunit of a human tRNA splicing ligase complex. Popow J, Englert M, Weitzer S, Schleiffer A, Mierzwa B, Mechtler K, Trowitzsch S, Will CL, Lührmann R, Söll D, Martinez J. Science. 2011 Feb 11;331(6018):760-4. PMID: 21311021
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