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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > SLC22A16 (aa97-110) Antibody (internal region)
SLC22A16 (aa97-110) Antibody (internal region)
Peptide-affinity purified goat antibody
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- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q86VW1 |
| Other Accession | NP_149116.2, 85413 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 64614 Da |
| Gene ID | 85413 |
|---|---|
| Other Names | Solute carrier family 22 member 16, Carnitine transporter 2, CT2, Fly-like putative transporter 2, FLIPT2, Flipt 2, Organic cation transporter OKB1, Organic cation/carnitine transporter 6, SLC22A16, OCT6 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC22A16 (aa97-110) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC22A16 (HGNC:20302) |
|---|---|
| Synonyms | OCT6 |
| Function | Facilitative organic cation transporter that mediates the transport of carnitine as well as the polyamine spermidine (PubMed:12089149, PubMed:20037140). Mediates the partially Na(+)- dependent bidirectional transport of carnitine (PubMed:12089149). May mediate L-carnitine secretion from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa (PubMed:12089149). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis |
| Tissue Location | Expressed in testis and epididymis (at protein level) (PubMed:12384147, PubMed:12089149, PubMed:15963465). Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase (PubMed:17197897). Expressed at lower levels in adult tissues including bone marrow (at protein level) (PubMed:12372408, PubMed:12384147, PubMed:15963465). Expressed in hematopoietic cells, including CD34(+) leukocytes (PubMed:12384147) Expressed in fetal liver (at protein level), brain, lung, kidney, heart, skeletal muscle, spleen and thymus (PubMed:12372408, PubMed:12384147, PubMed:15963465). Expressed in leukemia cells (PubMed:12384147). Abundantly expressed in ovarian cancer clear-cell adenocarcinoma (PubMed:17581421). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5. Aouida M, Poulin R, Ramotar D. J Biol Chem. 2010 Feb 26;285(9):6275-84. PMID: 20037140
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$ 216.00
Cat# AF3642a
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