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GPR83 (aa59-71) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NYM4 |
| Other Accession | NP_057624.3, 10888, 14608 (mouse), 140595 (rat) |
| Reactivity | Human, Mouse, Rat |
| Predicted | Pig, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 48339 Da |
| Gene ID | 10888 |
|---|---|
| Other Names | Probable G-protein coupled receptor 83, G-protein coupled receptor 72, GPR83, GPR72, KIAA1540 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPR83 (aa59-71) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPR83 (HGNC:4523) |
|---|---|
| Function | G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN (PubMed:27117253). Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P30731}; Multi-pass membrane protein. Note=Colocalizes with GPR171 in the paraventricular nucleus. Colocalizes with the ghrelin receptor GHSR1A in the hypothalamus. {ECO:0000250|UniProtKB:P30731} |
| Tissue Location | Highly expressed in the brain and spinal cord, and found in lower concentrations in the thymus and other tissues |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The immunizing peptide represents part of an extracellular domain.
References
Inflammation in vivo is modulated by GPR83 isoform-4 but not GPR83 isoform 1 expression in regulatory T cells. Hansen W, Westendorf AM, Toepfer T, Mauel S, Geffers R, Gruber AD, Buer J. Genes Immun. 2010 Jun;11(4):357-61. PMID: 20200545
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