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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > P2rx4 (mouse) Antibody (internal region)
P2rx4 (mouse) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q99571 |
| Other Accession | NP_035156.2, 5025, 18438 (mouse), 29659 (rat) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Pig, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 43369 Da |
| Gene ID | 5025 |
|---|---|
| Other Names | P2X purinoceptor 4, P2X4, ATP receptor, Purinergic receptor, P2RX4 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | P2rx4 (mouse) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | P2RX4 |
|---|---|
| Function | ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:9016352). CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4 (By similarity). Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology (PubMed:35165166). Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (By similarity). Participates also in basal T-cell activity without TCR/CD3 stimulation (By similarity). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (PubMed:35165166). Upon activation, drives microglia motility via the PI3K/Akt pathway (By similarity). Could also function as an ATP-gated cation channel of lysosomal membranes (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:F8W463}. Lysosome membrane; Multi-pass membrane protein |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Regenerative protein thymosin beta-4 is a novel regulator of purinergic signaling. Freeman KW, Bowman BR, Zetter BR. FASEB J. 2011 Mar;25(3):907-15. PMID: 21106936
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$ 464.00
Cat# AF3725a
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