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Praja-1 / RNF70 (aa285-298) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q8NG27 |
| Other Accession | NP_660095.1, NP_001027568.1, NP_071763.2, 64219 |
| Predicted | Human, Mouse |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 71002 Da |
| Gene ID | 64219 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase Praja-1, Praja1, 6.3.2.-, RING finger protein 70, PJA1, RNF70 |
| Dilution | E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Praja-1 / RNF70 (aa285-298) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PJA1 |
|---|---|
| Synonyms | RNF70 |
| Function | Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting. |
| Tissue Location | Expressed in various regions of the brain including the cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Highest levels in the cerebral cortex |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize all reported isoforms (NP_660095.1; NP_001027568.1; NP_071763.2).
References
PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins. Zoabi M, Sadeh R, de Bie P, Marquez VE, Ciechanover A. Biochem Biophys Res Commun. 2011 May 13;408(3):393-8. PMID: 21513699
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