Synaptotagmin-10 Antibody (internal region, near C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | Q6XYQ8 |
Other Accession | NP_945343.1, 341359, 54526 (mouse), 60567 (rat) |
Predicted | Human, Mouse, Rat, Pig, Dog |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 59127 Da |
Gene ID | 341359 |
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Other Names | Synaptotagmin-10, Synaptotagmin X, SytX, SYT10 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Synaptotagmin-10 Antibody (internal region, near C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SYT10 |
---|---|
Function | Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). |
Cellular Location | Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q9R0N4}; Single-pass membrane protein. Note=Localizes to neuronal vesicles containing IGF1 that are not enriched at synapses. Does not colocalize with synaptic vesicles or with the Golgi apparatus. {ECO:0000250|UniProtKB:Q9R0N4} |
Tissue Location | Expressed only in pancreas, lung and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
References
Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. Fukuda M, Kanno E, Mikoshiba K. J Biol Chem. 1999 Oct 29;274(44):31421-7. PMID: 10531343
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