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complement C3 (aa681-693) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | P01024 |
| Other Accession | NP_000055.2, 718 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 187148 Da |
| Gene ID | 718 |
|---|---|
| Other Names | Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, Complement C3 beta chain, C3-beta-c, C3bc, Complement C3 alpha chain, C3a anaphylatoxin, Acylation stimulating protein, ASP, C3adesArg, Complement C3b alpha' chain, Complement C3c alpha' chain fragment 1, Complement C3dg fragment, Complement C3g fragment, Complement C3d fragment, Complement C3f fragment, Complement C3c alpha' chain fragment 2, C3, CPAMD1 |
| Dilution | E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | complement C3 (aa681-693) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | C3 {ECO:0000303|PubMed:2579379, ECO:0000312|HGNC:HGNC:1318} |
|---|---|
| Function | Precursor of non-enzymatic components of the classical, alternative, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. |
| Cellular Location | Secreted. [C3a anaphylatoxin]: Secreted |
| Tissue Location | Plasma.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize the C3 alpha chain and C3a anaphylatoxin,
References
IgG autoantibodies against deposited C3 inhibit macrophage-mediated apoptotic cell engulfment in systemic autoimmunity. Kenyon KD, Cole C, Crawford F, Kappler JW, Thurman JM, Bratton DL, Boackle SA, Henson PM. J Immunol. 2011 Sep 1;187(5):2101-11. PMID: 21813769
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