MC4R Antibody (N-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | P32245 |
Other Accession | NP_005903.2, 4160 |
Predicted | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 36943 Da |
Gene ID | 4160 |
---|---|
Other Names | Melanocortin receptor 4, MC4-R, MC4R |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MC4R Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MC4R |
---|---|
Function | Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Brain, placental, and gut tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The immunizing peptide represents extracellular part of the protein
References
Constitutive cholesterol-dependent endocytosis of melanocortin-4 receptor (MC4R) is essential to maintain receptor responsiveness to ?-melanocyte-stimulating hormone (?-MSH). McDaniel FK, Molden BM, Mohammad S, Baldini G, McPike L, Narducci P, Granell S, Baldini G. The Journal of biological chemistry 2012 Jun 287 (26): 21873-90. PMID: 22544740
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