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carbonic anhydrase XII (aa188-199) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | O43570 |
| Other Accession | NP_001209.1, NP_996808.1, 771 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 39451 Da |
| Gene ID | 771 |
|---|---|
| Other Names | Carbonic anhydrase 12, 4.2.1.1, Carbonate dehydratase XII, Carbonic anhydrase XII, CA-XII, Tumor antigen HOM-RCC-3.1.3, CA12 |
| Dilution | WB~~1:1000 IHC~~1:100~500 E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | carbonic anhydrase XII (aa188-199) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CA12 (HGNC:1371) |
|---|---|
| Function | Reversible hydration of carbon dioxide. |
| Cellular Location | Membrane; Single-pass type I membrane protein. Cell membrane |
| Tissue Location | Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue Moderately expressed in pancreas, ovary and testis. Expressed in sweat glands and bronchiolar epithelium (PubMed:26911677) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (NP_001209.1; NP_996808.1).
References
Autosomal recessive hyponatremia due to isolated salt wasting in sweat associated with a mutation in the active site of Carbonic Anhydrase 12. Muhammad E et al. Hum Genet. 2011 Apr;129(4):397-405. PMID: 21184099
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