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syndecan 1 / CD138 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P18827 |
| Other Accession | NP_002988.3, 6382 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 32462 Da |
| Gene ID | 6382 |
|---|---|
| Other Names | Syndecan-1, SYND1, CD138, SDC1, SDC |
| Dilution | WB~~1:1000 E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | syndecan 1 / CD138 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SDC1 (HGNC:10658) |
|---|---|
| Synonyms | SDC |
| Function | Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). |
| Cellular Location | Membrane; Single-pass type I membrane protein. Secreted Secreted, extracellular exosome Note=Shedding of the ectodomain produces a soluble form |
| Tissue Location | Detected in placenta (at protein level) (PubMed:32337544). Detected in fibroblasts (at protein level) (PubMed:36213313). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Reported variants represent identical protein: NP_001006947.1, NP_002988.3.
References
Removal of syndecan-1 promotes TRAIL-induced apoptosis in myeloma cells. Wu YH, Yang CY, Chien WL, Lin KI, Lai MZ. Journal of immunology (Baltimore, Md. : 1950) 2012 Mar 188 (6): 2914-21. PMID: 22308310
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