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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > VPS16 (isoform 1) Antibody (internal region)
VPS16 (isoform 1) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H269 |
| Other Accession | NP_072097.2, 64601, 80743 (mouse), 296159 (rat) |
| Reactivity | Human, Mouse, Rat |
| Predicted | Pig, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 94694 Da |
| Gene ID | 64601 |
|---|---|
| Other Names | Vacuolar protein sorting-associated protein 16 homolog, hVPS16, VPS16 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | VPS16 (isoform 1) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VPS16 |
|---|---|
| Function | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for recruitment of VPS33A to the HOPS complex (PubMed:23901104). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS33A but not VPS33B (PubMed:25783203). The function in autophagosome- lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770). |
| Cellular Location | Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q920Q4}. Cytoplasmic vesicle, autophagosome. Note=Colocalizes with AP- 3, clathrin, Rab5 and Rab7b (By similarity). Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes. {ECO:0000250|UniProtKB:Q920Q4, ECO:0000305} |
| Tissue Location | Ubiquitous. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize reported isoform 1 (NP_072097.2) only.
References
Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33. Huizing M, Didier A, Walenta J, Anikster Y, Gahl WA, Krämer H. Gene. 2001 Feb 21;264(2):241-7. PMID: 11250079
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$ 341.00
Cat# AF4117a
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