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> home > Products > Primary Antibodies > Antibody Collections > Antiviral defense > Goat Anti-APOBEC3D Antibody (internal region)
Goat Anti-APOBEC3D Antibody (internal region)
Purified Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q96AK3 |
| Other Accession | NP_689639.1 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 |
| Calculated MW | 46598 Da |
| Gene ID | 140564 |
|---|---|
| Other Names | APOBEC3D; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D (putative); ARP6; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Peptide with sequence C-ATDSQETRPGRA, from the internal region of the protein sequence according to NP_689639.1. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-APOBEC3D Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | APOBEC3D (HGNC:17354) |
|---|---|
| Function | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent mechanisms (PubMed:16920826, PubMed:20062055, PubMed:21835787). Exhibits antiviral activity against HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single- strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA (PubMed:16920826). The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Also inhibits the mobility of LTR and non-LTR retrotransposons (PubMed:27428332). |
| Cellular Location | Cytoplasm. Cytoplasm, P-body |
| Tissue Location | Expressed in lymphoid organs. Also detected in non- lymphoid tissues including lung. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism. Stenglein MD, Harris RS. J Biol Chem. 2006 Jun 23;281(25):16837-41. Epub 2006 Apr 28.
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$ 255.00
Cat# AF4152a
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