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> home > Products > Primary Antibodies > Signal Transduction > Goat Anti-CYP26A1 Antibody (internal region)
Goat Anti-CYP26A1 Antibody (internal region)
Purified Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| IHC, ICC, E |
|---|---|
| Primary Accession | O43174 |
| Other Accession | NP_000774.2, NP_476498.1 |
| Reactivity | Human |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 |
| Calculated MW | 56199 Da |
| Gene ID | 1592 |
|---|---|
| Other Names | CYP26A1; cytochrome P450, family 26, subfamily A, polypeptide 1; CP26; CYP26; P450RAI; P450RAI1; P450, retinoic acid-inactivating, 1; cytochrome P450, subfamily XXVIA, polypeptide 1; retinoic acid 4-hydroxylase; retinoic acid-metabolizing cytochrome |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Peptide with sequence C-NLPARFTHFHGE, from the internal region of the protein sequence according to NP_000774.2; NP_476498.1. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-CYP26A1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CYP26A1 {ECO:0000303|PubMed:26937021, ECO:0000312|HGNC:HGNC:2603} |
|---|---|
| Function | A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (PubMed:22020119, PubMed:9228017, PubMed:9716180). RAs exist as at least four different isomers: all- trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling (PubMed:22020119, PubMed:9228017, PubMed:9716180). Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (Probable). Involved in the convertion of atRA to all-trans-4-oxo-RA. Able to metabolize other RAs such as 9-cis, 13-cis and 9,13-di-cis RA (By similarity) (PubMed:9228017). Can oxidize all-trans-13,14- dihydroretinoate (DRA) to metabolites which could include all-trans-4- oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all- trans-18-hydroxy-DRA (By similarity). May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (PubMed:26937021). |
| Cellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein |
| Tissue Location | Expressed in most fetal and adult tissues with highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain (PubMed:9826557). Expressed at high levels in lung, pancreas, skin and uterus (at protein level) (PubMed:22020119). Lower expression level is detected in spleen, kidney, intestine and adipose tissue (at protein level) (PubMed:22020119). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Murine toxicology and pharmacokinetics of novel retinoic acid metabolism blocking agents Patel JB, Khandelwal A, Chopra P, Handratta VD, Njar VC Cancer Chemother Pharmacol. 2007 Nov;60(6):899-905
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$ 341.00
Cat# AF4156a
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