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Goat Anti-ASIC1 Antibody (C Terminus)
Purified Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P78348 |
| Other Accession | 11419(mouse), 79123(rat), NP_064423.2, NP_001086.2, NP_001243759.1 |
| Reactivity | Mouse |
| Predicted | Human, Mouse, Rat, Pig, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 |
| Calculated MW | 59909 Da |
| Gene ID | 41 |
|---|---|
| Other Names | ASIC1; acid-sensing (proton-gated) ion channel 1; ACCN2; ASIC; BNaC2; Cation channel, amiloride-sensitive, neuronal, 2; acid-sensing ion channel 1; acid-sensing ion channel 1a protein; amiloride-sensitive cation channel 2, neuronal; brain sodium channel 2 |
| Dilution | WB~~1:1000 E~~N/A |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Peptide with sequence C-NILPHHPARGT, from the C Terminus of the protein sequence according to NP_064423.2; NP_001086.2; NP_001243759.1. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-ASIC1 Antibody (C Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ASIC1 (HGNC:100) |
|---|---|
| Function | Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory (PubMed:21036899, PubMed:32915133, PubMed:34319232). Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents (PubMed:21036899). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:21036899). Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines. Modulates neuronal activity in the circuits underlying innate fear (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q6NXK8}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q6NXK8}. Note=Isolated in synaptosomes from the dendritic synapses of neurons {ECO:0000250|UniProtKB:Q6NXK8} |
| Tissue Location | Expressed in neurons throughout the central and peripheral nervous system. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant. Hoagland EN, Sherwood TW, Lee KG, Walker CJ, Askwith CC. The Journal of biological chemistry 2010 Dec 285 (53): 41852-62.
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$ 423.00
Cat# AF4209a
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