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> home > Products > Primary Antibodies > Signal Transduction > Goat Anti-SLC40A1 Antibody (internal region)
Goat Anti-SLC40A1 Antibody (internal region)
Purified Goat Polyclonal Antibody
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NP59 |
| Other Accession | NP_055400.1 |
| Reactivity | Human |
| Predicted | Human, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 |
| Calculated MW | 62542 Da |
| Gene ID | 30061 |
|---|---|
| Other Names | SLC40A1; solute carrier family 40 (iron-regulated transporter), member 1; FPN1; HFE4; IREG1; MST079; MTP1; SLC11A3; iron regulated gene 1; putative ferroportin 1 variant IIIB; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3; solute carrier family 40 member 1 |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Peptide with sequence C-ELKQLNLHKDTEPKP, from the internal region of the protein sequence according to NP_055400.1. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-SLC40A1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC40A1 (HGNC:10909) |
|---|---|
| Function | Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed:15692071, PubMed:22178646, PubMed:22682227, PubMed:24304836, PubMed:29237594, PubMed:29599243, PubMed:30247984). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Localized to the basolateral membrane of hepatocytoma WIF-B cells. |
| Tissue Location | Detected in erythrocytes (at protein level) (PubMed:23219802). Expressed in placenta, intestine, muscle and spleen (PubMed:10747949). Highly expressed in mature red blood (PubMed:29599243). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination. Qiao B, Sugianto P, Fung E, Del-Castillo-Rueda A, Moran-Jimenez MJ, Ganz T, Nemeth E. Cell metabolism 2012 Jun 15 (6): 918-24.
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$ 423.00
Cat# AF4222a
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