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Goat Anti-IL3RA / CD123 Antibody (internal region)
Purified Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P26951 |
| Other Accession | NP_002174.1, NP_001254642.1 |
| Reactivity | Human |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 |
| Calculated MW | 43330 Da |
| Gene ID | 3563 |
|---|---|
| Other Names | IL3RA; interleukin 3 receptor, alpha (low affinity); CD123; IL3R; IL3RAY; IL3RX; IL3RY; hIL-3Ra; CD123 antigen; IL-3 receptor alpha SP2 isoform; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; interleukin-3 receptor subunit alpha |
| Dilution | WB~~1:1000 E~~N/A |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Peptide with sequence RQQYECLHYKTD, from the internal region of the protein sequence according to NP_002174.1; NP_001254642.1. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-IL3RA / CD123 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IL3RA (HGNC:6012) |
|---|---|
| Synonyms | IL3R |
| Function | Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:10527461). Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Identification of CD123+ myeloid dendritic cells as an early-stage immature subset with strong tumoristatic potential. Shi J, Ikeda K, Maeda Y, Shinagawa K, Ohtsuka A, Yamamura H, Tanimoto M. Cancer letters 2008 Oct 270 (1): 19-29.
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