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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Goat Anti-GRPR Antibody (internal region)
Goat Anti-GRPR Antibody (internal region)
Purified Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | P30550 |
| Other Accession | NP_005305.1 |
| Predicted | Human, Pig, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 |
| Calculated MW | 43199 Da |
| Gene ID | 2925 |
|---|---|
| Other Names | GRPR; gastrin-releasing peptide receptor; BB2; GRP-R; GRP-preferring bombesin receptor; bombesin receptor 2 |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Peptide with sequence C-HPFHEESTNQT, from the internal region of the protein sequence according to NP_005305.1. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-GRPR Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GRPR |
|---|---|
| Function | Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide- expressing cells which leads to enhanced auditory fear memories (By similarity). Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in pancreas (PubMed:11245983). Also expressed in stomach, adrenal cortex and brain (PubMed:11245983) In brain, expressed in cells throughout the cortex (PubMed:34610277) |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter. Xiao D, Wang J, Hampton LL, Weber HC. Gene 2001 Feb 264 (1): 95-103.
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$ 255.00
Cat# AF4258a
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