Goat Anti-HMBS Antibody (internal region)
Purified Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | P08397 |
Other Accession | NP_000181.2, NP_001019553.1, NP_001245137.1, NP_001245138.1 |
Reactivity | Human |
Predicted | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 |
Calculated MW | 39330 Da |
Gene ID | 3145 |
---|---|
Other Names | HMBS; hydroxymethylbilane synthase; PBG-D; PBGD; PORC; UPS; porphobilinogen deaminase; porphyria, acute; Chester type; pre-uroporphyrinogen synthase; uroporphyrinogen I synthase; uroporphyrinogen I synthetase |
Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
Immunogen | Peptide with sequence C-HLEFRSIRGNLNTR, from the internal region of the protein sequence according to NP_000181.2; NP_001019553.1; NP_001245137.1; NP_001245138.1. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Goat Anti-HMBS Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HMBS |
---|---|
Synonyms | PBGD, UPS |
Function | As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen (PubMed:18936296, PubMed:19138865, PubMed:23815679, PubMed:18004775). Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact (PubMed:18936296). |
Cellular Location | Cytoplasm. |
Tissue Location | [Isoform 1]: Is ubiquitously expressed. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Seven novel genetic mutations within the 5'UTR and the housekeeping promoter of HMBS gene responsible for the non-erythroid form of acute intermittent porphyria. Brancaleoni V, Granata F, Colancecco A, Tavazzi D, Cappellini MD, Di Pierro E. Blood cells, molecules & diseases 49 (3-4): 147-51.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.