Goat Anti-SLC7A6 / y+LAT-2 (C Terminus) Antibody
Purified Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q92536 |
Other Accession | NP_003974.3, 9057 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 56828 Da |
Gene ID | 9057 |
---|---|
Other Names | SLC7A6; solute carrier family 7 (amino acid transporter light chain, y+L system), member 6; LAT-2; LAT3; y+LAT-2; Y+L amino acid transporter 2; amino acid permease; cationic amino acid transporter, y+ system; solute carrier family 7 (cationic amino acid t |
Target/Specificity | Reported variants represent identical protein: NP_003974.3, NP_001070253.1 |
Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
Immunogen | Peptide with sequence C-ELDVAEEKKDERKTD, from the C Terminus of the protein sequence according to NP_003974.3. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Goat Anti-SLC7A6 / y+LAT-2 (C Terminus) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC7A6 (HGNC:11064) |
---|---|
Function | Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (PubMed:9829974, PubMed:10903140, PubMed:16785209, PubMed:31705628, PubMed:15756301, PubMed:11311135, PubMed:17329401, PubMed:14603368, PubMed:19562367). Also exchanges L-arginine with L-lysine in a sodium-independent manner (PubMed:10903140). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (PubMed:10903140). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (PubMed:17197568). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Expressed in normal fibroblasts and those from LPI patients (PubMed:11078698). Also expressed in HUVECs, monocytes, RPE cells, and various carcinoma cell lines (PubMed:11742806, PubMed:14603368, PubMed:15280038, PubMed:17197568, PubMed:17329401) Expressed in brain, heart, testis, kidney, small intestine and parotis (PubMed:10903140). Highly expressed in T lymphocytes (PubMed:31705628) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Nguyen HT, Merlin D.Nguyen HT, Merlin D.Nguyen HT, Merlin D.Nguyen HT, Merlin D.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.