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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat Anti-SLC7A7 / y+LAT-1 Antibody (N Terminus)
Goat Anti-SLC7A7 / y+LAT-1 Antibody (N Terminus)
Purified Goat Polyclonal Antibody
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UM01 |
| Other Accession | NP_001119577.1, 9056 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 55991 Da |
| Gene ID | 9056 |
|---|---|
| Other Names | SLC7A7; solute carrier family 7 (amino acid transporter light chain, y+L system), member 7; LAT3; LPI; MOP-2; Y+LAT1; y+LAT-1; Y+L amino acid transporter 1; monocyte amino acid permease 2; solute carrier family 7 (cationic amino acid transporter, y+ syste |
| Target/Specificity | Reported variants represent identical protein: NP_001119577.1, NP_001119578.1 |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Peptide with sequence SQPEVETSPLGD-C, from the N Terminus of the protein sequence according to NP_001119577.1. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-SLC7A7 / y+LAT-1 Antibody (N Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC7A7 (HGNC:11065) |
|---|---|
| Function | Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine (PubMed:9878049, PubMed:9829974, PubMed:17329401, PubMed:10080182, PubMed:10655553, PubMed:15756301, PubMed:15776427, PubMed:14603368). Also mediates arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells (PubMed:15280038, PubMed:31705628). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity). |
| Cellular Location | Basolateral cell membrane; Multi-pass membrane protein |
| Tissue Location | Highest expression in kidney and peripheral blood leukocytes (PubMed:9829974). Weaker expression is observed in lung, heart, placenta, spleen, testis and small intestine (PubMed:9829974) Expressed in normal fibroblasts and those from LPI patients (PubMed:10080183, PubMed:11078698). Also expressed in HUVECs, monocytes, retinal pigment epithelial cells, and various carcinoma cell lines, with highest expression in a colon-carcinoma cell line (PubMed:11742806, PubMed:15280038, PubMed:17197568, PubMed:17329401) |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Nguyen HT, Merlin D.Nguyen HT, Merlin D.Nguyen HT, Merlin D.Nguyen HT, Merlin D.
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$ 341.00
Cat# AF4319a
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