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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-IL6R / CD126 (isoform 1) Antibody
Goat anti-IL6R / CD126 (isoform 1) Antibody
Peptide-affinity purified goat antibody
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Application 
| Pep-ELISA |
|---|---|
| Primary Accession | P08887 |
| Other Accession | NP_000556.1 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | IL6R |
| Calculated MW | 51548 Da |
| Gene ID | 3570 |
|---|---|
| Other Names | IL6R; interleukin 6 receptor ; HGNC:6019; CD126; IL-6R-1; IL-6R-alpha; IL6RA; MGC104991 ; CD126 antigen; interleukin 6 receptor alpha subunit |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | This antibody is expected to recognise isoform 1 only (NP_000556.1) |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-IL6R / CD126 (isoform 1) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IL6R (HGNC:6019) |
|---|---|
| Function | Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal (PubMed:28265003). Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis (PubMed:30995492, PubMed:31235509). The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans- signaling'. Alternatively, 'cluster signaling' occurs when membrane- bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable). |
| Cellular Location | [Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:P22272}; Single-pass type I membrane protein [Soluble interleukin-6 receptor subunit alpha]: Secreted |
| Tissue Location | [Isoform 2]: Expressed in peripheral blood mononuclear cells and weakly found in urine and serum. 1%-20% of the total sIL6R in plasma is generated by alternative splicing (PubMed:28060820). |
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$ 216.00
Cat# AF4338a
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