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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-NR5A2 / LRH1 (aa328-338) Antibody
Goat anti-NR5A2 / LRH1 (aa328-338) Antibody
Peptide-affinity purified goat antibody
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Application 
| WB, IHC, Pep-ELISA |
|---|---|
| Primary Accession | O00482 |
| Other Accession | NP_995582.1, NP_003813.1 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | NR5A2 |
| Calculated MW | 61331 Da |
| Gene ID | 2494 |
|---|---|
| Other Names | NR5A2; nuclear receptor subfamily 5, group A, member 2; B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; LRH-1; LRH1; hB1F-2; CYP7A promoter-binding factor; alpha-1-fetoprotein transcription factor; b1-binding factor, hepatocyte transcription factor which activat |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | This antibody is expected to recognize both reported isoforms (NP_995582.1; NP_003813.1). |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-NR5A2 / LRH1 (aa328-338) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NR5A2 |
|---|---|
| Synonyms | B1F, CPF, FTF |
| Function | Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti- inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38 (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells |
Research Areas
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Application Protocols
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$ 341.00
Cat# AF4346a
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