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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-UXT, Biotinylated Antibody
Goat anti-UXT, Biotinylated Antibody
Peptide-affinity purified goat antibody
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC, Pep-ELISA |
|---|---|
| Primary Accession | Q9UBK9 |
| Other Accession | NP_705582.1, NP_004173.1 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | UXT |
| Calculated MW | 18246 Da |
| Gene ID | 8409 |
|---|---|
| Other Names | UXT; ubiquitously expressed prefoldin like chaperone; ART-27; STAP1; SKP2-associated alpha PFD 1; androgen receptor trapped clone 27 protein; ubiquitously expressed transcript protein; ubiquitously-expressed, prefoldin-like chaperone |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | This antibody is expected to recognize both reported isoforms (NP_004173.1; NP_705582.1). |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-UXT, Biotinylated Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UXT |
|---|---|
| Function | Involved in gene transcription regulation (PubMed:28106301, PubMed:21730289). Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription (PubMed:11854421, PubMed:21730289). Together with URI1, associates with chromatin to the NKX3-1 promoter region (PubMed:21730289). Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm (PubMed:28106301). May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity (PubMed:17620405, PubMed:21307340). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:17554592). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). |
| Cellular Location | [Isoform 1]: Cytoplasm Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole Note=Predominantly localizes to the nucleus (PubMed:16221885) Localizes to spindle pole during mitosis (PubMed:16221885) |
| Tissue Location | Ubiquitous (PubMed:10087202, PubMed:11854421, PubMed:17635584, PubMed:11827465). Expressed in prostate epithelial cells (PubMed:21730289). Expressed in mammary epithelial cells (PubMed:28106301). Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus (PubMed:11854421, PubMed:17635584, PubMed:11827465) Overexpressed in a number of tumor tissues (PubMed:11854421, PubMed:16221885, PubMed:28106301). |
Research Areas
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Application Protocols
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$ 341.00
Cat# AF4405a
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