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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-Duffy / FY / DARC, Biotinylated Antibody
Goat anti-Duffy / FY / DARC, Biotinylated Antibody
Peptide-affinity purified goat antibody
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Application 
| WB, IHC, FC, Pep-ELISA |
|---|---|
| Primary Accession | Q16570 |
| Other Accession | NP_001116423.1, NP_002027.2 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | ACKR1 |
| Calculated MW | 35553 Da |
| Gene ID | 2532 |
|---|---|
| Other Names | ACKR1; atypical chemokine receptor 1 (Duffy blood group); CCBP1; CD234; DARC; Dfy; FY; GPD; GpFy; WBCQ1; Duffy antigen chemokine receptor; Duffy blood group antigen; Duffy blood group, atypical chemokine receptor; Duffy blood group, chemokine receptor; Fy |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | This antibody is expected to recognize both reported isoforms (NP_001116423.1; NP_002027.2). |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-Duffy / FY / DARC, Biotinylated Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ACKR1 |
|---|---|
| Synonyms | DARC, FY, GPD |
| Function | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels. |
| Cellular Location | Early endosome. Recycling endosome. Membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane |
| Tissue Location | Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venules throughout the body, except in the adult liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium |
Research Areas
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$ 341.00
Cat# AF4444a
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