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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-ARX Antibody
Goat anti-ARX Antibody
Peptide-affinity purified goat antibody
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- BACKGROUND
Application 
| WB, Pep-ELISA |
|---|---|
| Primary Accession | Q96QS3 |
| Other Accession | NP_620689.1 |
| Reactivity | Human, Mouse, Rat, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | ARX |
| Calculated MW | 58160 Da |
| Gene ID | 170302 |
|---|---|
| Other Names | ARX; aristaless related homeobox; ISSX; MRX29; MRX32; MRX33; MRX36; MRX38; MRX43; MRX54; MRXS1; PRTS; Infantile spasm syndrome, X-linked; aristaless-related homeobox, X-linked |
| Dilution | WB~~1:1000 Pep-ELISA~~N/A |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-ARX Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARX |
|---|---|
| Function | Transcription factor (PubMed:22194193, PubMed:31691806). Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes, such as histone demethylase KDM5C (PubMed:22194193, PubMed:31691806). Positively modulates transcription of KDM5C (PubMed:31691806). Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (PubMed:31691806). Required for normal brain development (PubMed:11889467, PubMed:12379852, PubMed:14722918). Plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain (By similarity). May also be involved in axonal guidance in the floor plate (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138} |
| Tissue Location | Expressed predominantly in fetal and adult brain and skeletal muscle. Expression is specific to the telencephalon and ventral thalamus. There is an absence of expression in the cerebellum throughout development and also in adult. |
Research Areas
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Application Protocols
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$ 423.00
Cat# AF4468a
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