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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-DCUN1D1, Biotinlyated Antibody
Goat anti-DCUN1D1, Biotinlyated Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, Pep-ELISA |
|---|---|
| Primary Accession | Q96GG9 |
| Other Accession | NP_065691.2 |
| Reactivity | Human, Mouse, Bovine |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | DCUN1D1 |
| Calculated MW | 30124 Da |
| Gene ID | 54165 |
|---|---|
| Other Names | DCUN1D1; DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae); DCUN1L1; RP42; SCCRO; SCRO; Tes3; RP42 homolog; squamous cell carcinoma-related oncogene |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-DCUN1D1, Biotinlyated Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DCUN1D1 (HGNC:18184) |
|---|---|
| Function | Part of an E3 ubiquitin ligase complex for neddylation (PubMed:18826954). Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes (PubMed:26906416, PubMed:23201271, PubMed:19617556, PubMed:23401859). Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity). |
| Cellular Location | Nucleus. Cytoplasm Note=The ubiquitinated form is localized in the cytoplasm |
| Tissue Location | Expressed in pancreas, kidney, placenta, brain and heart. Weakly or not expressed in liver, skeletal muscle and lung Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas |
Research Areas
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$ 341.00
Cat# AF4474a
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