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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-LYP / PTPN22 Antibody
Goat anti-LYP / PTPN22 Antibody
Peptide-affinity purified goat antibody
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Application 
| IHC, IF, FC, Pep-ELISA |
|---|---|
| Primary Accession | Q9Y2R2 |
| Other Accession | NP_057051, NP_036543.4, NP_001180360.1, NP_001295226.1 |
| Reactivity | Human, Chimpanzee |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | PTPN22 |
| Calculated MW | 91705 Da |
| Gene ID | 26191 |
|---|---|
| Other Names | PTPN22; LYP; Lyp1; Lyp2; protein tyrosine phosphatase, non-receptor type 22 (lymphoid); protein tyrosine phosphatase homolog; lymphoid-specific protein tyrosine phosphatase |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | This antibody is specific for human LYP1 and will not cross-react with LYP2. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-LYP / PTPN22 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PTPN22 |
|---|---|
| Synonyms | PTPN8 |
| Function | Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3 (PubMed:27043286). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P29352}. |
| Tissue Location | Expressed in bone marrow, B and T-cells, PBMCs, natural killer cells, monocytes, dendritic cells and neutrophils (PubMed:15208781). Both isoform 1 and 4 are predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells. |
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$ 341.00
Cat# AF4503a
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