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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-Doublecortin / DCX (aa69-81) Antibody
Goat anti-Doublecortin / DCX (aa69-81) Antibody
Peptide-affinity purified goat antibody
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Application 
| IF, FC, Pep-ELISA |
|---|---|
| Primary Accession | O43602 |
| Other Accession | NP_000546.2 |
| Reactivity | Human, Bovine |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | DCX |
| Calculated MW | 40574 Da |
| Gene ID | 1641 |
|---|---|
| Other Names | DCX; doublecortin; RP5-914P14.1; DBCN; DC; FLJ51296; LISX; SCLH; XLIS; OTTHUMP00000023860; OTTHUMP00000216316; doublecortex; doublin; lis-X; lissencephalin-X; neuronal migration protein doublecortin |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | This antibody is expected to recognize reported isoform a (NP_000546.2) only. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-Doublecortin / DCX (aa69-81) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DCX |
|---|---|
| Synonyms | DBCN, LISX |
| Function | Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. |
| Cellular Location | Cytoplasm. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q9ESI7}. Note=Localizes at neurite tips. {ECO:0000250|UniProtKB:Q9ESI7} |
| Tissue Location | Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas |
Research Areas
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$ 341.00
Cat# AF4508a
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