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Goat anti-BRM Antibody
Peptide-affinity purified goat antibody
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Application 
| IF, Pep-ELISA |
|---|---|
| Primary Accession | P51531 |
| Other Accession | NP_003061.3, NP_620614.2 |
| Reactivity | Human, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | SMARCA2 |
| Calculated MW | 181279 Da |
| Gene ID | 6595 |
|---|---|
| Other Names | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 ; BAF190 ; BRM ; FLJ36757 ; MGC74511 ; SNF2 ; SNF2L2 ; SNF2LA ; SWI2 ; Sth1p ; hBRM ; hSNF2a; SNF2-alpha; SNF2-like 2 ; SNF2/SWI2-like protein 2 ; SWI/SNF-re |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | This antibody is expected to recognise both reported isoforms (NP_003061.3; NP_620614.2) |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-BRM Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SMARCA2 (HGNC:11098) |
|---|---|
| Function | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self- renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). |
| Cellular Location | Nucleus. Note=Localizes to sites of DNA damage |
Research Areas
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$ 341.00
Cat# AF4522a
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