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Goat anti-GLI1 Antibody
Peptide-affinity purified goat antibody
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- BACKGROUND
Application 
| IF, FC, Pep-ELISA |
|---|---|
| Primary Accession | P08151 |
| Other Accession | NP_005260.1, NP_001153517.1, NP_001161081.1 |
| Reactivity | Human, Mouse, Rat, Dog, Bovine |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | GLI1 |
| Calculated MW | 117904 Da |
| Gene ID | 2735 |
|---|---|
| Other Names | GLI1; GLI family zinc finger 1; GLI; glioma-associated oncogene family zinc finger 1; glioma-associated oncogene homolog 1 (zinc finger protein); oncogene GLI; zinc finger protein GLI1 |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | This antibody is expected to recognize the reported isoforms (NP_005260.1; NP_001153517.1; NP_001161081.1). |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-GLI1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GLI1 |
|---|---|
| Synonyms | GLI |
| Function | Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24076122, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). |
| Cellular Location | Cytoplasm. Nucleus. Note=Tethered in the cytoplasm by binding to SUFU (PubMed:10806483). Activation and translocation to the nucleus is promoted by interaction with STK36 (PubMed:10806483). Phosphorylation by ULK3 may promote nuclear localization (PubMed:19878745). Translocation to the nucleus is promoted by interaction with ZIC1 (PubMed:11238441) |
| Tissue Location | Detected in testis (at protein level) (PubMed:2105456). Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract (PubMed:19878745). Isoform 1 is detected in brain, spleen, pancreas, liver, kidney and placenta; isoform 2 is not detectable in these tissues (PubMed:19706761) |
Research Areas
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Application Protocols
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$ 341.00
Cat# AF4524a
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