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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-SCRIB / Scribble Antibody
Goat anti-SCRIB / Scribble Antibody
Peptide-affinity purified goat antibody
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Application 
| WB, IF, Pep-ELISA |
|---|---|
| Primary Accession | Q14160 |
| Other Accession | NP_874365.3, NP_056171.3 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | SCRIB |
| Calculated MW | 174915 Da |
| Gene ID | 23513 |
|---|---|
| Other Names | SCRIB; scribbled homolog (Drosophila); CRIB1; SCRB1; SCRIB1; Vartul; scribble |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | This antibody is expected to recognize both reported isoforms (NP_874365.3; NP_056171.3). |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-SCRIB / Scribble Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SCRIB |
|---|---|
| Synonyms | CRIB1, KIAA0147, LAP4, SCRB1, VARTUL |
| Function | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:19041750, PubMed:18716323, PubMed:18641685, PubMed:16965391, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Most probably functions in the establishment of apico- basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling (PubMed:18716323, PubMed:18641685). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity. |
| Cellular Location | Cell membrane; Peripheral membrane protein. Cell junction. Cell junction, adherens junction. Cell projection, lamellipodium. Cytoplasm. Postsynapse. Presynapse. Note=Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. In a subset of CD4+ T-cells, colocalizes with CRTAM at the immunological synapse during the late phase of T-cell activation (By similarity) {ECO:0000250|UniProtKB:Q80U72} |
| Tissue Location | Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level). |
Research Areas
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$ 341.00
Cat# AF4525a
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