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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-EHD1 Antibody
Goat anti-EHD1 Antibody
Peptide-affinity purified goat antibody
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Application 
| WB, IHC, IF, FC, Pep-ELISA |
|---|---|
| Primary Accession | Q9H4M9 |
| Other Accession | NP_001269373.1, NP_001269374.1 |
| Reactivity | Human, Mouse, Rat, Bovine |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | EHD1 |
| Calculated MW | 60627 Da |
| Gene ID | 10938 |
|---|---|
| Other Names | EHD1; PAST; PAST1; H-PAST; HPAST1; EH-domain containing 1; testilin; FLJ42622; FLJ44618; OTTHUMP00000069747 |
| Dilution | WB~~1:1000 IHC~~1:100~500 IF~~1:50~200 FC~~1:10~50 Pep-ELISA~~N/A |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-EHD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EHD1 (HGNC:3242) |
|---|---|
| Function | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis (PubMed:31615969). Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250). |
| Cellular Location | Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane {ECO:0000250|UniProtKB:Q9WVK4}; Peripheral membrane protein; Cytoplasmic side. Cell projection, cilium membrane; Peripheral membrane protein; Cytoplasmic side. Note=Preferentially associates with tubular recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:19864458, PubMed:23596323). Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes (By similarity). Localizes to the ciliary pocket from where the cilium protrudes (PubMed:25686250). Colocalizes with BACE1 in tubulovesicular cytoplasmic membranes. Colocalizes with BACE1 and APP amyloid beta proteins in hippocampal mossy fiber terminals (By similarity). {ECO:0000250|UniProtKB:Q9WVK4, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:25686250} |
| Tissue Location | Highly expressed in testis. |
Research Areas
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Application Protocols
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$ 464.00
Cat# AF4535a
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