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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-GRIN2A (aa211-224) Antibody
Goat anti-GRIN2A (aa211-224) Antibody
Peptide-affinity purified goat antibody
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Application 
| IF, Pep-ELISA |
|---|---|
| Primary Accession | Q12879 |
| Other Accession | NP_000824.1, NP_001127880.1 |
| Reactivity | Human, Mouse, Rat, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | GRIN2A |
| Calculated MW | 165283 Da |
| Gene ID | 2903 |
|---|---|
| Other Names | GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDAR2A; NR2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; NMDA receptor subtype 2A; OTTHUMP |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | This antibody is expected to recognize both reported isoforms (NP_000824.1; NP_001127880.1). The immunizing peptide represents part of an extra-cellular domain. Reported variants represent identical protein: NP_001127879.1, NP_000824.1 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-GRIN2A (aa211-224) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GRIN2A |
|---|---|
| Synonyms | NMDAR2A |
| Function | Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B (PubMed:26919761, PubMed:26875626). Contributes to the slow phase of excitatory postsynaptic current, long- term synaptic potentiation, and learning (By similarity). |
| Cellular Location | Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q00959}. Cell membrane; Multi-pass membrane protein. Synapse {ECO:0000250|UniProtKB:P35436} Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q00959}; Multi-pass membrane protein. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P35436}. Note=Expression at the dendrite cell membrane and at synapses is regulated by SORCS2 and the retromer complex. {ECO:0000250|UniProtKB:P35436} |
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$ 341.00
Cat# AF4539a
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