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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat Anti-NCOR1 Antibody
Goat Anti-NCOR1 Antibody
Peptide-affinity purified goat antibody
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Application 
| IF, Pep-ELISA |
|---|---|
| Primary Accession | O75376 |
| Other Accession | NP_006302.2 |
| Reactivity | Human, Mouse, Rat, Dog, Bovine |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | NCOR1 |
| Calculated MW | 270210 Da |
| Gene ID | 9611 |
|---|---|
| Other Names | NCOR1, nuclear receptor co-repressor 1, KIAA1047, MGC104216, N-CoR, TRAC1, hCIT529I10, hN-CoR, thyroid hormone- and retinoic acid receptor-associated corepressor 1 |
| Dilution | IF~~1:50~200 Pep-ELISA~~N/A |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
| Immunogen | Peptide with sequence C-SYDNIKNAREGTRSP, from the internal region of the protein sequence according to NP_006302.2. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-NCOR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NCOR1 |
|---|---|
| Synonyms | KIAA1047 |
| Function | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624}. |
Research Areas
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Application Protocols
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$ 423.00
Cat# AF4555a
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