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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat Anti-VGLUT1 Antibody
Goat Anti-VGLUT1 Antibody
Peptide-affinity purified goat antibody
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Application 
| IHC, IF, Pep-ELISA |
|---|---|
| Primary Accession | Q9P2U7 |
| Other Accession | NP_064705.1 |
| Reactivity | Human, Mouse, Rat, Dog, Bovine |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | SLC17A7 |
| Calculated MW | 61613 Da |
| Gene ID | 57030 |
|---|---|
| Other Names | SLC17A7, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7, BNPI, VGLUT1, brain-specific Na-dependent inorganic phosphate cotransporter, solute carrier family 17, member 7, vesicular glutamate transporter 1 |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
| Immunogen | Peptide with sequence C-HDQLAGSDDSEMED, from the internal region of the protein sequence according to NP_064705.1. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-VGLUT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC17A7 (HGNC:16704) |
|---|---|
| Function | Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:10820226). At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (By similarity). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (By similarity). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). Moreover, may function as a K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (By similarity). The vesicular K(+)/H(+) antiport activity is electroneutral (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (PubMed:10820226). The symporter activity is driven by an inside negative membrane potential and is electrogenic (By similarity). Is necessary for synaptic signaling of visual-evoked responses from photoreceptors (By similarity). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q3TXX4}. Cell membrane; Multi-pass membrane protein. Synapse, synaptosome {ECO:0000250|UniProtKB:Q3TXX4} |
| Tissue Location | Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe |
Research Areas
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$ 341.00
Cat# AF4557a
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