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KD-Validated Anti-MAP1LC3A Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | Q9H492 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 1960 |
| Calculated MW | Predicted, 14 kDa, observed, 14,16 kDa |
| Gene Name | MAP1LC3A |
| Aliases | MAP1LC3A; Microtubule Associated Protein 1 Light Chain 3 Alpha; MAP1BLC3; MAP1ALC3; ATG8E; LC3A; LC3; Microtubule-Associated Proteins 1A/1B Light Chain 3A; Autophagy-Related Ubiquitin-Like Modifier LC3 A; MAP1 Light Chain 3-Like Protein 1; MAP1A/MAP1B Light Chain 3 A; MAP1A/MAP1B LC3 A; Microtubule-Associated Protein 1 Light Chain 3 Alpha; Microtubule-Associated Proteins 1A/1B Light Chain 3; Autophagy-Related Protein LC3 A; MAP1A/1B Light Chain 3 A |
| Immunogen | A synthesized peptide derived from human MAP1LC3A |
| Gene ID | 84557 |
|---|---|
| Other Names | Microtubule-associated protein 1 light chain 3 alpha, Autophagy-related protein LC3 A, Autophagy-related ubiquitin-like modifier LC3 A, MAP1 light chain 3-like protein 1, Microtubule-associated proteins 1A/1B light chain 3A, MAP1A/MAP1B LC3 A, MAP1A/MAP1B light chain 3 A, MAP1LC3A |
| Name | MAP1LC3A |
|---|---|
| Function | Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006537, PubMed:31006538). |
| Cellular Location | Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Endomembrane system; Lipid-anchor. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q91VR7}. Note=LC3-II binds to the autophagic membranes. |
| Tissue Location | Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1011
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