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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-14-3-3 gamma Rabbit Monoclonal Antibody
KD-Validated Anti-14-3-3 gamma Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P61981 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 1970 |
| Calculated MW | Predicted, 28 kDa , observed, 28 kDa |
| Gene Name | YWHAG |
| Aliases | YWHAG; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma; 14-3-3GAMMA; PPP1R170; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Gamma Polypeptide; Protein Phosphatase 1, Regulatory Subunit 170; Protein Kinase C Inhibitor Protein 1; 14-3-3 Protein Gamma; KCIP-1; 14-3-3 Gamma; 14-3-3γ; 14-3-3G; EIEE56; DEE56 |
| Immunogen | A synthesized peptide derived from human 14-3-3 gamma |
| Gene ID | 7532 |
|---|---|
| Other Names | 14-3-3 protein gamma, Protein kinase C inhibitor protein 1, KCIP-1, 14-3-3 protein gamma, N-terminally processed, YWHAG (HGNC:12852) |
| Name | YWHAG (HGNC:12852) |
|---|---|
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L- glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). |
| Cellular Location | Cytoplasm, cytosol. Mitochondrion matrix. Note=Translocates to the mitochondrial matrix following induction of MALM (mitochondrial protein catabolic process). |
| Tissue Location | Highly expressed in brain, skeletal muscle, and heart. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1013
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