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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-CLPX Rabbit Monoclonal Antibody
KD-Validated Anti-CLPX Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | O76031 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB5980 |
| Calculated MW | Predicted, 69 kDa, observed, 60 kDa |
| Gene Name | CLPX |
| Aliases | Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit X; ATP-Dependent Clp Protease ATP-Binding Subunit ClpX-Like, Mitochondrial; ClpX (Caseinolytic Protease X, E. Coli) Homolog ; ClpX Caseinolytic Protease X Homolog (E. Coli); Energy-Dependent Regulator Of Proteolysis; ClpX Caseinolytic Peptidase X Homolog; ClpX Caseinolytic Protease X Homolog; EPP2 |
| Immunogen | A synthesized peptide derived from human CLPX |
| Gene ID | 10845 |
|---|---|
| Other Names | ATP-dependent clpX-like chaperone, mitochondrial, 3.6.4.10, ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial, Caseinolytic mitochondrial matrix peptidase chaperone subunit X {ECO:0000312|HGNC:HGNC:2088}, CLPX (HGNC:2088) |
| Name | CLPX (HGNC:2088) |
|---|---|
| Function | ATP-dependent chaperone that functions as an unfoldase. As part of the ClpXP protease complex, it recognizes specific protein substrates, unfolds them using energy derived from ATP hydrolysis, and then translocates them to the proteolytic subunit (CLPP) of the ClpXP complex for degradation (PubMed:11923310, PubMed:22710082, PubMed:28874591). Thanks to its chaperone activity, it also functions in the incorporation of the pyridoxal phosphate cofactor into 5- aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis (PubMed:28874591). This chaperone is also involved in the control of mtDNA nucleoid distribution, by regulating mitochondrial transcription factor A (TFAM) activity (PubMed:22841477). |
| Cellular Location | Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid |
| Tissue Location | Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain, placenta, lung, kidney and pancreas. |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1031
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