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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-MERTK Rabbit Monoclonal Antibody
KD-Validated Anti-MERTK Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q12866 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 2070 |
| Calculated MW | Predicted, 110 kDa , observed, 188 kDa |
| Gene Name | MERTK |
| Aliases | MERTK; MER Proto-Oncogene, Tyrosine Kinase; RP38; MER; C-Mer Proto-Oncogene Tyrosine Kinase; Receptor Tyrosine Kinase MerTK; Tyrosine-Protein Kinase Mer; Proto-Oncogene C-Mer; EC 2.7.10.1; Tyro12; C-Eyk; MER Receptor Tyrosine Kinase; STK Kinase; EC 2.7.10; TYRO12; C-Mer; C-EYK; Mer |
| Immunogen | A synthesized peptide derived from human MERTK |
| Gene ID | 10461 |
|---|---|
| Other Names | Tyrosine-protein kinase Mer, 2.7.10.1, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, MERTK, MER |
| Name | MERTK |
|---|---|
| Synonyms | MER |
| Function | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment (PubMed:32640697). Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1046
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