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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Histone acetyltransferase 1 Rabbit Monoclonal Antibody
KD-Validated Anti-Histone acetyltransferase 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | O14929 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 2090 |
| Calculated MW | Predicted, 50 kDa , observed, 45 kDa |
| Gene Name | HAT1 |
| Aliases | HAT1; Histone Acetyltransferase 1; KAT1; Histone Acetyltransferase Type B Catalytic Subunit; EC 2.3.1.48 |
| Immunogen | A synthesized peptide derived from human KAT1 / HAT1 |
| Gene ID | 8520 |
|---|---|
| Other Names | Histone acetyltransferase type B catalytic subunit, 2.3.1.48, Histone acetyltransferase 1, HAT1, KAT1 |
| Name | HAT1 |
|---|---|
| Synonyms | KAT1 |
| Function | Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair (PubMed:20953179, PubMed:23653357, PubMed:31278053, PubMed:32081014). Coordinates histone production and acetylation via H4 promoter binding (PubMed:31278053). Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac) (PubMed:11585814, PubMed:22615379). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression (PubMed:31278053). Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks (PubMed:23653357). In addition, acetylates other substrates such as chromatin-related proteins (PubMed:32081014). Also acetylates RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation (PubMed:31812350). |
| Cellular Location | [Isoform A]: Nucleus matrix Mitochondrion |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1051
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