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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-JUP Rabbit Monoclonal Antibody
KD-Validated Anti-JUP Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P14923 |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB6055 |
| Calculated MW | Predicted, 82 kDa, observed, 75 kDa |
| Gene Name | JUP |
| Aliases | JUP; Junction Plakoglobin; DP3; DPIII; CTNNG; PDGB; PKGB; PG; Catenin (Cadherin-Associated Protein), Gamma 80kDa; Desmosomal Protein 3; Desmoplakin III; Desmoplakin-3; Catenin Gamma |
| Immunogen | A synthesized peptide derived from human Catenin gamma |
| Gene ID | 3728 |
|---|---|
| Other Names | Junction plakoglobin, Catenin gamma, Desmoplakin III, Desmoplakin-3, JUP (HGNC:6207) |
| Name | JUP (HGNC:6207) |
|---|---|
| Function | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). |
| Cellular Location | Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cytoplasm {ECO:0000250|UniProtKB:Q9PVF7}. Cell junction {ECO:0000250|UniProtKB:Q9PVF7}. Nucleus {ECO:0000250|UniProtKB:Q9PVF7} Note=Cytoplasmic in a soluble and membrane-associated form. Colocalizes with DSG4 at desmosomes (PubMed:21495994) |
| Tissue Location | Expressed in the heart (at protein level). |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI1054
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