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> home > Products > Primary Antibodies > Antibody Collections > Ovary positive > KD-Validated Anti-PCBP2 Rabbit Monoclonal Antibody
KD-Validated Anti-PCBP2 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q15366 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 2110 |
| Calculated MW | Predicted, 34-39 kDa , observed, 35,39 kDa |
| Gene Name | PCBP2 |
| Aliases | PCBP2; Poly(RC) Binding Protein 2; Poly(RC)-Binding Protein 2; HNRNPE2; HNRPE2; Heterogeneous Nuclear Ribonucleoprotein E2; Heterogenous Nuclear Ribonucleoprotein E2; Alpha-CP2; HnRNP-E2; HnRNP E2; Epididymis Secretory Sperm Binding Protein; HNRNP-E2 |
| Immunogen | A synthesized peptide derived from human PCBP2 |
| Gene ID | 5094 |
|---|---|
| Other Names | Poly(rC)-binding protein 2, Alpha-CP2, Heterogeneous nuclear ribonucleoprotein E2, hnRNP E2, PCBP2 {ECO:0000303|PubMed:7607214, ECO:0000312|HGNC:HGNC:8648} |
| Name | PCBP2 {ECO:0000303|PubMed:7607214, ECO:0000312|HGNC:HGNC:8648} |
|---|---|
| Function | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid- like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). |
| Cellular Location | Nucleus. Cytoplasm. Note=Loosely bound in the nucleus (PubMed:7607214). May shuttle between the nucleus and the cytoplasm (PubMed:7607214). |
| Tissue Location | Detected in all tissues examined. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1061
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